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Search Results for " epoxide hydrolase "

57

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7898	AUDA	Epoxide Hydrolase	Metabolism
	AUDA 是可溶性环氧化物水解酶 (sEH) 抑制剂，在小鼠和人 sEH 的IC50分别为 18 和 69 nM，具有抗炎特性。
T12974	Soluble epoxide hydrolase inhibitor	Others	Others
	Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4).
T7199	TPPU	Epoxide Hydrolase	Metabolism
	TPPU 是一种可溶性环氧化物水解酶(sEH)抑制剂，对猴子和人类的IC50分别为37和3.7 nM。
T14557	BI-1935	Epoxide Hydrolase	Metabolism
	BI-1935 是可溶性环氧化物水解酶抑制剂，用于与心血管疾病相关的疾病的研究。
T17158	trans-AUCB t-AUCB	Epoxide Hydrolase	Metabolism
	trans-AUCB (t-AUCB) 是口服具有活力的、选择性的可溶性环氧水解酶 (sEH) 抑制剂，对人，小鼠和大鼠的 sEH 的IC50分别为 1.3 nM，8 nM，8 nM。它具有抗神经胶质瘤特性。
T83857	Soluble Epoxide Hydrolase PROTAC 1a sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a
	Soluble epoxide hydrolase (sEH) PROTAC 1a是一种利用蛋白质降解靶向嵌合体(PROTAC)技术，通过连接区域将cereblon配体1与sEH抑制剂t-TUCB结合。该化合物通过促进sEH的降解，特异性抑制sEH的水解酶活性(IC50 = 0.8 nM)，相较于其磷酸酶活性(IC50 = >10,000 nM)具有较高选择性。sEH PROTAC 1a还特定促进细胞质中而非过氧体中的sEH降解，并通过溶酶体而非蛋白酶体实现其降解。它能够降低thapsigargin诱导的HepG2与293T细胞中磷酸化的inositol-requiring enzyme 1α (IRE1α)水平和X-box结合蛋白1 (XBP1)剪接，表明能减少ER应激。
T10900	CUDA	PPAR; Epoxide Hydrolase	DNA Damage/DNA Repair; Metabolism
	CUDA 是一种可溶性环氧水解酶抑制剂，对小鼠 sEH 和人 sEH 作用的 IC50分别为 11.1 和 112 nM。它能选择性地上调过氧化物酶体增殖激活受体 PPARα的活性，有用于心血管疾病的研究潜力。
T14315	AR-9281 APAU	Epoxide Hydrolase	Metabolism
	AR-9281 (APAU) 是选择性的可溶性环氧化物水解酶抑制剂，可用于研究高血压和 2 型糖尿病。
T11147	EC5026 BPN-19186	Epoxide Hydrolase	Metabolism
	EC5026 (BPN-19186) 是首创的，非阿片类的，可溶性环氧水解酶 (sEH) 抑制剂，它可有效缓解发炎性和神经性疼痛。
T8844	Diflapolin	Others; FLAP; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Others
	Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂，具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性，IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成，IC50分别为 30 和 170 nM。
T17196	UC-1728 t-TUCB	Epoxide Hydrolase	Metabolism
	UC-1728 (t-TUCB) 是一种兔子可溶性环氧化物水解酶抑制剂，兔子肝脏中测得其IC50=2 nM。
T21859	ARM1	Aminopeptidase; Epoxide Hydrolase	Metabolism
	ARM1 是氨基肽酶和环氧化物水解酶抑制剂，IC50分别为为7.61 µM 和12.4 µM。
T15430	GSK2256294A GSK 2256294	Others; Epoxide Hydrolase	Metabolism; Others
	GSK2256294A (GSK 2256294) 是重组人、大鼠和小鼠 sEH 的有效特异性抑制剂，IC50 分别为 27 pM、61 pM 和 189 pM。
T0355	Valpromide Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide	Epoxide Hydrolase; HSV	Metabolism; Microbiology/Virology
	Valpromide (Dipropylacetamide) 是丙戊酸的羧酰胺衍生物，用于治疗癫痫和一些情感障碍。
T8315	1-Cyclohexyl-3-dodecyl urea CDU,N-Cyclohexyl-N-dodecyl urea,NCND	Epoxide Hydrolase	Metabolism
	1-Cyclohexyl-3-dodecyl urea (NCND) 是高选择性的可溶性环氧化物水解酶 (sEH) 抑制剂，能够增强血管紧张素 II (Ang II) 高血压中的环氧二十碳三烯酸 (EETs) 水平，并降低血压。
T23044	N,N'-Dicyclohexylurea DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲	Epoxide Hydrolase	Metabolism
	N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。
T2716	1,3-Diphenylurea	Epoxide Hydrolase	Metabolism
	1,3-Diphenylurea 与环氧化物水解酶活性有关。
T63536	Dual FAAH/sEH-IN-1	FAAH; Epoxide Hydrolase	Metabolism; Neuroscience
	Dual FAAH/sEH-IN-1 是具有高度亲和力的sEH(可溶性环氧水解酶) (IC50: 9.6 nM) 和FAAH(脂肪酸酰胺水解酶) (IC50: 7 nM) 双重抑制剂，具有抗炎活性。
T38367	CAY10640 sEH inhibitor-1	Epoxide Hydrolase	Metabolism
	CAY10640 (sEH inhibitor-1)一种有效的、具有口服活性、可溶于水的环氧化物水解酶 (sEH) 抑制剂，对人和鼠中的sEH 具有抑制作用，IC50s 分别为 0.4 和 5.3 nM。
T60358	sEH inhibitor-7	Epoxide Hydrolase	Metabolism
	sEH inhibitor-7是一种可溶性环氧化物水解酶（sEH）抑制剂，对人和小鼠的 sEH 有抑制作用，IC 50 s 分别为 6.2 μM 和0.15 μM 。sEH inhibitor-7与抗炎活性分子有关。
T9832	(Rac)-EC5026 Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]-	Epoxide Hydrolase	Metabolism
	(Rac)-EC5026 ((Rac)-BPN-19186) 是一种有效的可溶性环氧水解酶 (sEH) 哌啶抑制剂，Ki 值为 0.06 nM。(Rac)-EC5026 可用于帕金森氏病和路易体痴呆 (DLB) 的研究。
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increase...
T68786	Orniplabin
	Orniplabin, also known as SMTP-7 is a dual inhibitor of thrombolysis and soluble epoxide hydrolase. SMTP-7 promotes thrombolysis and inhibits soluble epoxide hydrolase.
T24778	sEH-IN-12 sEH inhibitor 12,sEH-inhibitor-12
	sEH-IN-12 is an effective inhibitor of the enzyme soluble epoxide hydrolase (sEH).
T68259	TUPS
	TUPS is a selective soluble epoxide hydrolase inhibitor which protects against isoprenaline-induced cardiac hypertrophy.
T37239	(±)19(20)-EpDTE
	(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA and can be further metabolized to (±)19(20)-DiHDTE by epoxide hydrolase.
T61541	sEH inhibitor-6
	sEH inhibitor-6 (Compound 3g) is a highly potent soluble epoxide hydrolase (sEH) inhibitor, exhibiting an IC 50 value of 0.5 nM [1].
T13042	SWE101	Others	Others
	SWE101 is a potent human and rat soluble epoxide hydrolase (sEH)-P inhibitor(IC50s of 4 μM and 2.8 μM, respectively).
T37226	(±)7(8)-EpDTE
	(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA, and can be further metabolized to (±)7(8)-DiHDTE by epoxide hydrolase.
T37334	(±)11,12-DiHETE
	(±)11,12-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11,12-DiHETE are increased over baseline after an oral dose of 1008 mg EPA.
T61690	mEH-IN-1
	mEH-IN-1 (Compound 62) is a potent inhibitor of microsomal epoxide hydrolase (mEH), with an IC50 value of 2.2 nM. mEH is an α/β-fold hydrolase enzyme that is widely expressed in various mammalian tissues, responsible for the hydrolysis of a diverse range of epoxide-containing molecules. This enzyme is primarily localized in the endoplasmic reticulum (ER) of eukaryotic cells. Research involving mEH-IN-1 can contribute to the understanding of preeclampsia, hypercholanemia, and cancer [1].
T72698	sEH inhibitor-14
	sEH inhibitor-14 (化合物 33)，一种苯并恶唑酮-5-尿素类似物，是一种效力显著的可溶性环氧化物水解酶 (Epoxide Hydrolase) 抑制剂，具有极低的半抑制浓度 (IC50=0.39 nM)。
T64136	sEH inhibitor-5
	sEH inhibitor-5 是一种 sEH (可溶性环氧化物水解酶) 的有效抑制剂 (IC50: 0.1 nM)。
T62425	sEH inhibitor-3
	sEH inhibitor-3 (compound 35) 是一种有效的、口服具有活力的可溶性环氧化物水解酶 (sEH) 抑制剂，能够作用于人 sEH (Ki: 0.75 nM)。
T64291	sEH inhibitor-1
	sEH inhibitor-1 (compound TCPU ) 是一种有效的、口服具有活力的可溶性环氧化物水解酶 (sEH) 抑制剂，对人和鼠 she 的 IC50 值分别为 0.4 和 5.3 nM。
T36074	S-NEPC
	Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation. S-NEPC is a colorimetric substrate used to measure sEH activity. It also is...
T37652	5(S),6(R)-DiHETE
	5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM.
T82452	Epoxy Fluor 7
	Epoxy Fluor 7是一种对可溶性环氧化物水解酶(sEH)有敏感反应的荧光底物，适用于人类和小鼠的酶。该化合物在被sEH水解后产生荧光，用于监测sEH的活性。
T35496	(±)13(14)-EpDPA
	Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 μM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±)13(14)-EpDPA and other epoxy m...
T63700	sEH inhibitor-4
	sEH inhibitor-4 (compound B15) has been identified as a potent soluble epoxide hydrolase (SEH) inhibitor with a remarkable inhibitory potency of 0.03 ± 0.01 nm. Intensive structural modification efforts led to the discovery of this compound for its ability to decrease inflammation and alleviate pain in the presence of SEH.
T38143	Elaidamide
	Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2).3 In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats.1References1. Cravatt, B.F., Prospero-Garcia, O., Siuzdak, G., et al. Chemical characterization of a family of brain lipids that induce sleep. Science 268(5216), 1506-150...
T35493	(±)10(11)-EpDPA
	Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in infla...
T79258	sEH inhibitor-16	Epoxide Hydrolase	Metabolism
	sEH inhibitor-16，作为一种可溶性环氧化物水解酶（sEH）抑制剂，具有2 nM的IC50值。它能够降低小鼠Cerulein诱导的急性胰腺炎（AP）的炎症损伤，适用于免疫炎症研究。
T63398	COX-2/sEH-IN-1
	COX-2/sEH-IN-1 是口服具有活力的 COX-2 (IC50: 1.24 μM) 和 sEH (IC50: 0.40 μM) 的双抑制剂，其中sEH 是一种可溶性环氧化物水解酶。COX-2/sEH-IN-1 可以增加抗炎作用、显著降低心血管风险。
T37236	(±)17(18)-DiHETE
	Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. (±)17(18)-DiHETE is one of the major metabolites produced when eicosapentaenoic acid (EPA) is incubated with various rat tissue homogenates or cynomolgus monkey seminal vesicles. The route of production of (±)17(18)-DiHETE likely proceeds through cytochrome P450-catalyzed epoxidation at the ω-3 double bond followed by conversion to the vicinal diols by epoxide hydrolase. EPA is also metabolized preferentially by...
T35497	(±)7(8)-EpDPA
	Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids. (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting ...
T35773	Gliotoxin-13C13 Gliotoxin-13C13
	Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutr...
T35457	(±)12(13)-DiHOME (±)12(13)-DiHOME,Isoleukotoxin diol
	(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. [1] It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. [2] 12(13)-DiHOME is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike isoleukotoxin, which is only toxic to cells containing sEH.[1] [2] Levels of 12(13)-DiHOME are increased in rat spinal cord following burn injury, and it enhances cold tolerance...
T64181	sEH/AChE-IN-1
	sEH/AChE-IN-1 (Compound 12a) 是一种可溶性环氧化物水解酶 (sEH) 和乙酰胆碱酯酶 (AChE) 的双重抑制剂。sEH/AChE-IN-1 具有对抗神经炎症和记忆障碍的累积效应。sEH/AChE-IN-1 对阿尔茨海默病 (AD) 表现出研究潜力。
T72875	sEH/AChE-IN-3
	sEH/AChE-IN-3 -15) 是一种有效的、可透过血脑屏障的 sEH(可溶性环氧水解酶)和 AChE(乙酰胆碱酯酶)的双重抑制剂，其 IC50分别为 0.4 nM (hsEH)、1.94 nM (hAChE)、615 (hBChE，丁酰胆碱酯酶)、4.3 nM (msEH) 和 2.61 nM (mAChE)。

化合物

Cat.No: T7898

Target: Epoxide Hydrolase

Soluble epoxide hydrolase inhibitor

Cat.No: T12974

Target: Others

Cat.No: T7199

Target: Epoxide Hydrolase

Cat.No: T14557

Target: Epoxide Hydrolase

Cat.No: T17158

Synonym: t-AUCB

Target: Epoxide Hydrolase

Soluble Epoxide Hydrolase PROTAC 1a

Cat.No: T83857

Synonym: sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a

Cat.No: T10900

Target: PPAR, Epoxide Hydrolase

Cat.No: T14315

Synonym: APAU

Target: Epoxide Hydrolase

Cat.No: T11147

Synonym: BPN-19186

Target: Epoxide Hydrolase

Cat.No: T8844

Target: Others, FLAP, Epoxide Hydrolase

Cat.No: T17196

Synonym: t-TUCB

Target: Epoxide Hydrolase

Cat.No: T21859

Target: Aminopeptidase, Epoxide Hydrolase

Cat.No: T15430

Synonym: GSK 2256294

Target: Others, Epoxide Hydrolase

Cat.No: T0355

Synonym: Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide

Target: Epoxide Hydrolase, HSV

1-Cyclohexyl-3-dodecyl urea

Cat.No: T8315

Synonym: CDU,N-Cyclohexyl-N-dodecyl urea,NCND

Target: Epoxide Hydrolase

N,N'-Dicyclohexylurea

Cat.No: T23044

Synonym: DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲

Target: Epoxide Hydrolase

1,3-Diphenylurea

Cat.No: T2716

Target: Epoxide Hydrolase

Dual FAAH/sEH-IN-1

Cat.No: T63536

Target: FAAH, Epoxide Hydrolase

Cat.No: T38367

Synonym: sEH inhibitor-1

Target: Epoxide Hydrolase

sEH inhibitor-7

Cat.No: T60358

Target: Epoxide Hydrolase

Cat.No: T9832

Synonym: Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]-

Target: Epoxide Hydrolase

Cat.No: T36696

Cat.No: T68786

Cat.No: T24778

Synonym: sEH inhibitor 12,sEH-inhibitor-12

Cat.No: T68259

(±)19(20)-EpDTE

Cat.No: T37239

sEH inhibitor-6

Cat.No: T61541

Cat.No: T13042

Target: Others

Cat.No: T37226

(±)11,12-DiHETE

Cat.No: T37334

Cat.No: T61690

sEH inhibitor-14

Cat.No: T72698

sEH inhibitor-5

Cat.No: T64136

sEH inhibitor-3

Cat.No: T62425

sEH inhibitor-1

Cat.No: T64291

Cat.No: T36074

5(S),6(R)-DiHETE

Cat.No: T37652

Cat.No: T82452

(±)13(14)-EpDPA

Cat.No: T35496

sEH inhibitor-4

Cat.No: T63700

Cat.No: T38143

(±)10(11)-EpDPA

Cat.No: T35493

sEH inhibitor-16

Cat.No: T79258

Target: Epoxide Hydrolase

Cat.No: T63398

(±)17(18)-DiHETE

Cat.No: T37236

Cat.No: T35497

Gliotoxin-13C13

Cat.No: T35773

Synonym: Gliotoxin-13C13

(±)12(13)-DiHOME

Cat.No: T35457

Synonym: (±)12(13)-DiHOME,Isoleukotoxin diol

Cat.No: T64181

Cat.No: T72875

Cat. No.	Product Name	Target	Signaling Pathways
TN6794	N-(3-methoxybenzyl)-octadecanamide	Others	Others
	N-(3-methoxybenzyl)-octadecanamide 从玛卡 (Lepidium meyenii Walp.) 转化而来。
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,

天然产物

N-(3-methoxybenzyl)-octadecanamide

Cat.No: TN6794

Target: Others

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

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